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Science 13 December 1974:
Vol. 186. no. 4168, pp. 1038 - 1040
DOI: 10.1126/science.186.4168.1038
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Articles

1agr-Hydroxyvitamin D2: A Potent Synthetic Analog of Vitamin D2

H. -Y. Peter Lam 1, H. K. Schnoes 1, and H. F. DeLuca 1

1 Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison 53706

A hydroxy analog of vitamin D2, 1agr-hydroxyvitamin D2, has been synthesized and tested for biological activity. This vitamin derivative is active in stimulating intestinal calcium transport and bone calcium mobilization in the rat and exhibits antirachitic activity. Its biopotency is comparable to that of the corresponding vitamin D3 analog, 1agr-hydroxyvitamin D3.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Current Understanding of the Molecular Actions of Vitamin D.
G. JONES, S. A. STRUGNELL, and H. F. DeLUCA (1998)
Physiol Rev 78, 1193-1231
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