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Science 6 December 1974:
Vol. 186. no. 4167, pp. 942 - 944
DOI: 10.1126/science.186.4167.942
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Articles

Guanosine 3',5'-Monophosphate in Sympathetic Ganglia: Increase Associated with Synaptic Transmission

Forrest F. Weight 1, Gary Petzold 2, and Paul Greengard 2

1 Laboratory of Neuropharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D. C. 20032
2 Departmient of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510

Brief stimulation of cholinergic preganglionic nerve fibers resulted in an increase in guanosine 3',5'-monophosphate (cyclic GMP) in the bullfrog sympathetic ganglion. When the release of synaptic transmitter was prevented by a high-magnesium, low-calcium Ringer solution, stimulation of preganglionic nerve fibers did not increase cyclic GMP in the ganglion. The increase in cyclic GMP caused by preganglionic stimulation was also blocked by the muscarinic antagonist, atropine. The data indicate that the increase in cyclic GMP is associated with synaptic transmission and support the possibility that cyclic GMP may mediate the postsynaptic action of acetylcholine at muscarinic cholinergic synapses.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Model for Pleiotropic Muscarinic Potentiation of Fast Synaptic Transmission.
H. Schobesberger, D. W. Wheeler, and J. P. Horn (2000)
J Neurophysiol 83, 1912-1923
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Synaptic potentials in sympathetic ganglia: are they mediated by cyclic nucleotides?.
N. Busis, F. Weight, and P. Smith (1978)
Science 200, 1079-1081
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Cyclic Nucleotides, Protein Phosphorylation and Synaptic Function.
K. G. Beam and P. Greengard (1976)
Cold Spring Harb Symp Quant Biol 40, 157-168
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Neurotransmitters increase cyclic nucleotides in postganglionic neurons: immunocytochemical demonstration.
J. Kebabian, F. Blood, A. Steiner, and P Greengard (1975)
Science 190, 157-159
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