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Science 29 November 1974:
Vol. 186. no. 4166, pp. 837 - 838
DOI: 10.1126/science.186.4166.837
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Articles

Hypoxemia and the Sudden Infant Death Syndrome

Richard L. Naeye 1

1 Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033

Infants with known chronic hypoxemia before death retained a large proportion of the brown fat cells that are normally replaced by white fat cells after birth. Many of these hypoxemic infants also had an abnormal retention of extramedullary hematopoiesis. These same abnormalities were found in many victims of the sudden infant death syndrome.


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Thermal Stress in Sudden Infant Death: Is There an Ambiguity With the Rebreathing Hypothesis?.
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Fetal cells in maternal blood of pregnancies with severe fetal growth restriction.
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Repetitive hypoxia rapidly depresses arousal from active sleep in newborn lambs.
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Oxidative Stress in Sudden Infant Death Syndrome.
S. Huggle, J. C. Hunsaker, C. M. Coyne, and D. L. Sparks (1996)
J Child Neurol 11, 433-438
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Increased ALZ-50 Immunoreactivity in Sudden Infant Death Syndrome.
D. L. Sparks, D. G. Davis, T. Mellert Bigelow, K. Rasheed, T. M. Landers, H. Liu, C. M. Coyne, and J. C. Hunsaker (1996)
J Child Neurol 11, 101-107
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The Timing of SIDS Deaths in Premature Infants in an Urban Population.
C. L. Lipsky, E. Gibson, J. A. Cullen, K. Rankin, and A. R. Spitzer (1995)
Clinical Pediatrics 34, 410-414
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Sudden Infant Death Syndrome: Altered Aminergic-Cholinergic Synaptic Markers in Hypothalamus.
D. L. Sparks and J. C. Hunsaker (1991)
J Child Neurol 6, 335-339
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Increased ALZ-50-Reactive Neurons in the Brains of SIDS Infants: An Indicator of Greater Neuronal Death?.
D. L. Sparks and J. C. Hunsaker (1991)
J Child Neurol 6, 123-127
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Infant Apnea Syndrome: A Prospective Evaluation of Etiologies.
P. Camfield, C. Camfield, P. Bagnell, and E. Rees (1982)
Clinical Pediatrics 21, 684-687
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Periodicity of sleep states is altered in infants at risk for the sudden infant death syndrome.
R. Harper, B Leake, H Hoffman, D. Walter, T Hoppenbrouwers, J Hodgman, and M. Sterman (1981)
Science 213, 1030-1032
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Laryngeal Mucous Gland Excess in Victims of Sudden Infant Death.
B. R. Fink and J. B. Beckwith (1980)
Arch Pediatr Adolesc Med 134, 144-146
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Infantile Atlantooccipital Instability: The Potential Danger of Extreme Extension.
F. H. Gilles, M. Bina, and A. Sotrel (1979)
Arch Pediatr Adolesc Med 133, 30-37
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Reversal of cardiopulmonary failure during active sleep in hypoxic kittens: implications for sudden infant death.
T. Baker and D. McGinty (1977)
Science 198, 419-421
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Impaired regulation of alveolar ventilation and the sudden infant death syndrome.
D. Shannon and D Kelly (1977)
Science 197, 367-368
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Sudden Infant Death Syndrome: A Prospective Study.
R. L. Naeye, B. Ladis, and J. S. Drage (1976)
Arch Pediatr Adolesc Med 130, 1207-1210
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Carotid body in the sudden infant death syndrome.
R. Naeye, R Fisher, M Ryser, and P Whalen (1976)
Science 191, 567-569
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Apneas during sleep in infants: possible relationship with sudden infant death syndrome.
C Guilleminault, R Peraita, M Souquet, and W. Dement (1975)
Science 190, 677-679
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