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Science 1 November 1974:
Vol. 186. no. 4162, pp. 456 - 458
DOI: 10.1126/science.186.4162.456
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Articles

Interspecies Conversion of Clostridium botulinum Type C to Clostridium novyi Type A by Bacteriophage

M. W. Eklund 1, F. T. Poysky 1, J. A. Meyers 1, and G. A. Pelroy 1

1 Pacific Utilization Research Center, National Marine Fisheries Services, National Oceanic and Atmospheric Administration, Seattle, Washington 98112

When Clostridium botulinum type C is cured of its prophage it simultaneously ceases to produce toxin. This nontoxigenic culture can then be converted to another toxigenic bacterial species, Clostridium novyi type A or to toxigenic Clostridium botulinum types C or D, by specific bacteriophages. The toxigenicity and type of toxin produced by these cultures depends upon the continued presence of these bacteriophages.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A PCR approach to determine the distribution of toxin genes in closely related Clostridium species: Clostridium botulinum type C and D neurotoxins and C2 toxin, and Clostridium novyi {alpha} toxin.
A. Heffron and I. R. Poxton (2007)
J. Med. Microbiol. 56, 196-201
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Infant Botulism: Epidemiological, Clinical, and Laboratory Aspects.
S. S. Arnon, T. F. Midura, S. A. Clay, R. M. Wood, and J. Chin (1977)
JAMA 237, 1946-1951
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Combination bacteriolytic therapy for the treatment of experimental tumors.
L. H. Dang, C. Bettegowda, D. L. Huso, K. W. Kinzler, and B. Vogelstein (2001)
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Science. ISSN 0036-8075 (print), 1095-9203 (online)