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Science 1 November 1974:
Vol. 186. no. 4162, pp. 444 - 445
DOI: 10.1126/science.186.4162.444
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Articles

Pancreatic Ribonuclease: Enzymic and Physiological Properties of a Cross-Linked Dimer

Jacques Bartholeyns 1 and Stanford Moore 1

1 The Rockefeller University. New York 10021

Monomeric ribonuclease A has very low activity toward typically double-stranded RNA's; the dimeric form of ribonuclease A obtained by cross linking the enzyme by dimethyl suberimidate has more than 78 times the activity of the monomer toward polyadenylate · polyuridylate and 440 times the activity of the monomer toward the double-stranded RNA of a virus from Penicillium chrysogenum. The half-life of the dimer in the bloodstream of the rat is 12 times that of the mononmer.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)