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Science 18 October 1974:
Vol. 186. no. 4160, pp. 265 - 267
DOI: 10.1126/science.186.4160.265
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Articles

N'-Nitrosonornicotine in Tobacco

Dietrich Hoffmann 1, Stephen S. Hecht 1, Raphael M. Ornaf 1, and Ernst L. Wynder 1

1 Divisions of Environmental Carcinogenesis and Epidemiology, Naylor Dana Institute for Disease Prevention, American Health Foundation, New York 10021

N'-Nitrosonornicotine, a potential carcinogen, has been positively identified in unburned tobacco. The amount in commercial U.S. tobacco products is between 1.9 to 88.6 parts per million, one of the highest values of an environmental nitrosamine yet reported. The amount in food and drink rarely exceeds 0.1 part per million. This compound is the first example of a potential organic carcinogen isolated from tobacco.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Enantiomeric composition of N'-nitrosonornicotine and N'-nitrosoanatabine in tobacco.
S. G. Carmella, E. J. McIntee, M. Chen, and S. S. Hecht (2000)
Carcinogenesis 21, 839-843
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