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Science 11 October 1974:
Vol. 186. no. 4159, pp. 150 - 151
DOI: 10.1126/science.186.4159.150
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Articles

Insulin Secretion by Anomers of D-Glucose

Atsushi Niki 1, Hatsumi Niki 1, Ichitomo Miwa 2, and Jun Okuda 2

1 Department of Internal Medicine, School of Dentistry, Aichigakuin University, Nagoya 464, Japan
2 Department of Clinical Biochemistry, Faculty of Pharmaceutical Science, Meijo University, Nagoya 468

Isolated rat islets were incubated for 5 minutes in the media containing either the agr or beta anomer of D-glucose (2 milligrams per milliliter). The amounts of secreted insulin and changes of anomers ratio were concomitantly determined. In spite of rapid mutarotation, significantly greater stimulation of insulin secretion was observed by agr-D-glucose as compared with beta-D-glucose.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Anomeric specificty of 3-0-methyl-D-glycopyranose against alloxan diabetes.
A. Rossini, G. Cahill Jr, D. Jeanioz, and R. Jeanioz (1975)
Science 188, 70-71
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