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Science 27 September 1974:
Vol. 185. no. 4157, pp. 1179 - 1181
DOI: 10.1126/science.185.4157.1179
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Articles

Centric Fusion, Satellite DNA, and DNA Polarity in Mouse Chromosomes

M. S. Lin 1 and R. L. Davidson 1

1 Clinical Genetics Division, Children's Hospital Medical Center, and Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston. Massachusetts 02115

A fluorescent staining technique has demonstrated a contralateral arrangement of fluorescent spots in the centromeric region of mouse metacentric chromosomes which have resulted from centric fusion. The results suggest that centric fusion involves the maintenance of DNA polaritv through the centromere and that the thymidine-rich chain of satellite DNA in the centromeric region is associated with the same DNA chain in every mouse autosome.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Pericentromeric organization at the fusion point of mouse Robertsonian translocation chromosomes.
S. Garagna, N. Marziliano, M. Zuccotti, J. B. Searle, E. Capanna, and C. A. Redi (2001)
PNAS 98, 171-175
   Abstract »    Full Text »    PDF »
H-Y antigen gene loci.
F. Thompson (1978)
Science 201, 842
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Science. ISSN 0036-8075 (print), 1095-9203 (online)