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Science 20 September 1974:
Vol. 185. no. 4156, pp. 1049 - 1053
DOI: 10.1126/science.185.4156.1049
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Articles

Reoviruslike Agent in Stools: Association with Infantile Diarrhea and Development of Serologic Tests

Albert Z. Kapikian 1, Hyun Wha Kim 2, Richard G. Wyatt 3, William J. Rodriguez 4, Sydney Ross 4, W. Lee Cline 3, Robert H. Parrott 4, and Robert M. Chanock 3

1 National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014
2 Children's Hospital, Washington, D.C. 20009
3 National Institute of Allergy and Infectious Diseases
4 Children's Hospital

Reoviruslike particles were visualized by electron microscopy in stool filtrates prepared from stools of infants and young children with severe acute gastroenteritis. Patients who had such particles in their stools and whose paired acute and convalescent serums were tested developed an antibody response to the reoviruslike agent, which was measured by immune electron microscopy and by complement fixation. The reoviruslike agent was antigenically related to the epizootic diarrhea of infant mice virus and the Nebraska calf diarrhea virus.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Group A Human Rotavirus Genomics: Evidence that Gene Constellations Are Influenced by Viral Protein Interactions.
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J. Virol. 82, 11106-11116
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Viral Gastroenteritis.
A. Z. Kapikian (1993)
JAMA 269, 627-630
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Rotavirus Gastroenteritis in the Washington, DC, Area: Incidence of Cases Resulting in Admission to the Hospital.
W. J. Rodriguez, H. W. Kim, C. D. Brandt, B. Bise, A. Z. Kapikian, R. M. Chanock, G. Curlin, and R. H. Parrott (1980)
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Enzyme-linked immunosorbent assay for identification of rotaviruses from different animal species.
R. Yolken, B Barbour, R. Wyatt, A. Kalica, A. Kapikian, and R. Chanock (1978)
Science 201, 259-262
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Viruses and Diarrhea--A Review.
M. C. Steinhoff (1978)
Arch Pediatr Adolesc Med 132, 302-307
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Human Reovirus-like Agent Infection: Occurrence in Adult Contacts of Pediatric Patients With Gastroenteritis.
H. W. Kim, C. D. Brandt, A. Z. Kapikian, R. G. Wyatt, J. O. Arrobio, W. J. Rodriguez, R. M. Chanock, and R. H. Parrott (1977)
JAMA 238, 404-407
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Enteropathogenicity of Escherichia coli.
E. NETER (1975)
Arch Pediatr Adolesc Med 129, 666-667
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