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Science 13 September 1974:
Vol. 185. no. 4155, pp. 944 - 946
DOI: 10.1126/science.185.4155.944
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Articles

Acetylcholine Noise: Analysis after Chemical Modification of Receptor

E. M. Landau 1 and D. Ben-Haim 1

1 Department of Physiology and Pharmacology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel

The elementary voltage pulses ("shot effects") produced by the action of acetylcholine molecules on the receptor were studied by analyzing the membrane voltage fluctuations ("noise") after acetylcholine application at the frog neuromuscular junction. The amplitude of these pulses was decreased after treatment with a disulfide-bond reducing agent. The shot effect may thus depend on the structure or conformation of the receptor molecule.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)