Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 16 August 1974:
Vol. 185. no. 4151, pp. 625 - 627
DOI: 10.1126/science.185.4151.625
Prev | Table of Contents | Next

Articles

Enduring Learning Deficits and Cerebral Synaptic Malformation from Exposure to 10 Parts of Halothane per Million

Kelvin L. Quimby 1, Lea J. Aschkenase 1, Robert E. Bowman 1, Jordan Katz 2, and Louis W. Chang 2

1 Psychology Department and Regional Primate Research Center, University of Wisconsin, Madison 53706
2 Departments of Anesthesiology and Pathology, University of Wisconsin Medical School, Madison 53706

Chronic exposure of rats to 10 parts of halothane per million during early life produced later deficits in learning a shock-motivated light-dark discrimination and a food-motivated maze pattern, correlated with enduring synaptic nembrane malformation in cerebral cortex. Adult exposure had no effect. Halothane may provide a useful analytical tool for study of brain. The behavioral-ultrastructural techniques also suggest a standard for assessing the safety of trace toxicants with central nervous system effects.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
An Assessment of the Effects of General Anesthetics on Developing Brain Structure and Neurocognitive Function.
A. W. Loepke and S. G. Soriano (2008)
Anesth. Analg. 106, 1681-1707
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)