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Science 9 August 1974:
Vol. 185. no. 4150, pp. 534 - 535
DOI: 10.1126/science.185.4150.534
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Articles

Absence of REM Rebound after Barbiturate Withdrawal

I. Feinberg 1, S. Hibi 2, C. Cavness 2, and J. March 2

1 Veterans Administration Hospital, San Francisco, California 94121, and Department of Psychiatry, University of California Medical School, San Francisco 94122
2 Veterans Administration Hospital, San Francisco

Administration of three different barbiturates reduced rapid eye movement (REM) sleep. Drug withdrawal led to a return to baseline REM] values without significant overshoot. Similar results are observed with administration of benzodiazepines in pharmacologically equivalent dosages; therefore, a distinction between these two drug classes on the basis of withdrawal effects on the sleep electroencephalogram appears unwarranted. Further investigation is required determine why high REM levels are sometimes associated with the withdrawal of sedative-hypnotic agents.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Flurazepam Effects on Sleep EEG: Visual, Computer, and Cycle Analysis.
I. Feinberg, G. Fein, J. M. Walker, L. J. Price, T. C. Floyd, and J. D. March (1979)
Arch Gen Psychiatry 36, 95-102
   Abstract »    PDF »
Sleep Amphetamine Effects in MBDS and Normal Subjects.
I. Feinberg, S. Hibi, M. Braun, C. Cavness, G. Westerman, and A. Small (1974)
Arch Gen Psychiatry 31, 723-731
   Abstract »    PDF »


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