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Science 2 August 1974:
Vol. 185. no. 4149, pp. 442 - 444
DOI: 10.1126/science.185.4149.442
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Articles

Lysosomal and Microsomal Glucuronidase: Genetic Variant Alters Electrophoretic Mobility of Both Hydrolases

Peter A. Lalley 1 and Thomas B. Shows 1

1 Roswell Park Memorial Institute, New York State Department of Health, Buffalo 14203

An electrophoretic variant of beta-glucuronidase is present in certain inbred mouse lines. The variant simultaneously affects the mobility of the lysosomal and microsomal forms of the enzyme. The difference is inherited as a single gene mapping at the position of the structural gene on chromosome 5. This confirms that beta-glucuronidase at both intracellular sites is coded by the same structural gene.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)