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Science 19 July 1974:
Vol. 185. no. 4147, pp. 281 - 283
DOI: 10.1126/science.185.4147.281
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Articles

Cation Dependence of High-Affinity Angiotensin II Binding to Adrenal Cortex Receptors

H. Glossmann 1, A. Baukal 1, and K. J. Catt 1

1 Section on Hormonal Regulation, Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014

The specific binding of monoiodinated angiotensin II by particulate receptors from the bovine adrenal cortex is enhanced by addition of sodium and potassium ions, but not other cations. In the presence of 140 millimolar sodium, increased uptake of angiotensin II by adrenal receptors is associated with the appearance of high-affinity binding sites with an association constant of 2 x 109 liters per mole.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Single Mutations at Asn295 and Leu305 in the Cytoplasmic Half of Transmembrane {alpha}-Helix Domain 7 of the AT1 Receptor Induce Promiscuous Agonist Specificity for Angiotensin II Fragments: A Pseudo-Constitutive Activity.
Y.-H. Feng, L. Zhou, R. Qiu, and R. Zeng (2005)
Mol. Pharmacol. 68, 347-355
   Abstract »    Full Text »    PDF »
International Union of Pharmacology. XXIII. The Angiotensin II Receptors.
M. de Gasparo, K. J. Catt, T. Inagami, J. W. Wright, and Th. Unger (2000)
Pharmacol. Rev. 52, 415-472
   Abstract »    Full Text »    PDF »


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