Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 5 July 1974:
Vol. 185. no. 4145, pp. 74 - 76
DOI: 10.1126/science.185.4145.74
Prev | Table of Contents | Next

Articles

Localization of Sister Chromatid Exchanges in Human Chromosomes

Samuel A. Latt 1

1 Department of Pediatrics and Center for Human Genetics, Harvard Medical School, Clinical Genetics Division, Children's Hospital Medical Center, Boston, Massachusetts 02115

The bromodeoxyuridine; sensitivity of 33258 Hoechst fluorescence allows microfluorometric analysis of sister chromatid exchanges in human metaphase chromosomes. The frequency of sister chromatid exchanges among chromosomes correlates with chromosome length. Exchanges appear to occur predominantly in interband regions, as defined by quinacrine fluorescence, or very near band-interband junctions. A few regions are involved unusually frequently.

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)