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Science 21 June 1974:
Vol. 184. no. 4143, pp. 1298 - 1299
DOI: 10.1126/science.184.4143.1298
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Articles

Selective Destruction of the Pigmented Epithelium in the Ciliary Body of the Eye

Shigekuni Okisaka 1, Toichiro Kuwabara 1, and Stanley I. Rapoport 2

1 Laboratory of Vision Research, National Eye Institute, Bethesda, Maryland 20014
2 Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland 20014

Perfusion of the internal carotid artery with hypertonic solution selectively destroys most of the pigmented epithelium of the ciliary body of the monkey eye, converts fenestrated endothelium of capillaries to continuous endothelium, and transiently breaks down the blood-aqueous barrier. The nonpigmented epithelium regenerates and the intraocular pressure returns to normal even though the pigmented epithelium is permanently destroyed.


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