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Science 14 June 1974:
Vol. 184. no. 4142, pp. 1188 - 1191
DOI: 10.1126/science.184.4142.1188
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Articles

Thyroid Hormone Action: In vitro Demonstration of Putative Receptors in Isolated Nuclei and Soluble Nuclear Extracts

Herbert H. Samuels 1, Jir S. Tsai 1, and Juan Casanova 1

1 Endocrine Division, Department of Medicine, New York University School of Medicine, New York 10016

Saturable binding activities for triiodothyronine were demonstrated in vitro with isolated nuclei and soluble nuclear extracts of rat liver, kidney, and cultured GH1 cells. The binding activity can be extracted from nuclei in soluble form with no significant change in hormone affinity and has properties of a nonhistone protein.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Molecular Basis of Thyroid Hormone-Dependent Brain Development.
J. H. Oppenheimer and H. L. Schwartz (1997)
Endocr. Rev. 18, 462-475
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Tissue-specific Stabilization of the Thyroid Hormone beta 1 Nuclear Receptor by Phosphorylation.
Y.-T. Ting, M. Bhat, R. Wong, and S.-y. Cheng (1997)
J. Biol. Chem. 272, 4129-4134
   Abstract »    Full Text »    PDF »
Thyroid hormone action at the cellular level.
J. Oppenheimer (1979)
Science 203, 971-979
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Thyroid hormones: effect of physiological concentrations on cultured cardiac cells.
J. Tsai and A Chen (1976)
Science 194, 202-204
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