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Science 14 June 1974:
Vol. 184. no. 4142, pp. 1183 - 1185
DOI: 10.1126/science.184.4142.1183
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Articles

Lateral Phase Separation of Lipids in Plasma Membranes: Effect of Temperature on the Mobility of Membrane Antigens

Valerie A. Petit 1 and Michael Edidin 1

1 Biology Department, Johns Hopkins University, Baltimore, Maryland 21218

Cooling populations of newly formed mouse human heterokaryons has effects on the intermixing of mouse and human surface antigens which indicate the occurrence of phase separations in membrane lipids. Antigen mixing, previously shown to be due to diffusion in the plane of the membrane, is retarded when cells are cooled from 37° to 21°C, but is then speeded by further cooling to 15°C. This result is in accord with observations on phase separations of lipids in artificial and bacterial membranes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Detection of Lipid Domains in Model and Cell Membranes by Fluorescence Lifetime Imaging Microscopy of Fluorescent Lipid Analogues.
M. Stockl, A. P. Plazzo, T. Korte, and A. Herrmann (2008)
J. Biol. Chem. 283, 30828-30837
   Abstract »    Full Text »    PDF »
Documentation of benchmark photographs that show the effects of the 1983 Borah Peak earthquake with some considerations for studies of scarp degradation.
M. N. MACHETTE (1987)
Bulletin of the Seismological Society of America 77, 771-783
   Abstract »    PDF »


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