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Science 3 May 1974:
Vol. 184. no. 4136, pp. 577 - 579
DOI: 10.1126/science.184.4136.577
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Articles

Oxygen Binding in Cyanmet Hybrid and Normal Hemoglobins: Applicability of Sequential and Two-State Concerted Models

Allen P. Minton 1

1 Laboratory of Biophysical Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014

The cyanmet hybrid hemoglobins agr2beta+CN2 and agr+CN2beta2 are widely held to be similar or equivalent in structure and subunit interactions to the partially oxygen-liganded species agr2(beta • O2)2 and (agr • O2)2beta2, respectively. An analysis of precise data on oxygen binding to the cyanmet hybrids and normal hemoglobin shows that if this is the case, then cooperative ligand binding in hemoglobin is more properly described by some model of the sequential type than by any twostate concerted model.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)