Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 3 May 1974:
Vol. 184. no. 4136, pp. 573 - 574
DOI: 10.1126/science.184.4136.573
Prev | Table of Contents | Next

Articles

Thiocarbamate Sulfoxides: Potent, Selective, and Biodegradable Herbicides

John E. Casida 1, Reed A. Gray 2, and Harry Tilles 3

1 Division of Entomology and Parasitology, University of California, Berkeley 94720
2 Agricultural Research Center, Stauffer Chemical Company, Mountain View, California 94040
3 Western Research Center, Stauffer Chemical Company, Richmond, California 94804

Sulfoxidation of thiocarbamates yields a new class of chemicals having increased herbicidal activity along with greater tolerance of corn and soybeans in greenhouse tests. However, their thermal stability is not favorable. These sulfoxides are intermediates in the mammalian metabolism of thiocarbamates, being formed by liver microsomal oxidases and cleaved in a system consisting of glutathione and a soluble enzyme from liver.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A direct role of SRY and SOX proteins in pre-mRNA splicing.
K. Ohe, E. Lalli, and P. Sassone-Corsi (2002)
PNAS
   Abstract »    Full Text »    PDF »
Self-generated DNA termini relax the specificity of SgrAI restriction endonuclease.
J. Bitinaite and I. Schildkraut (2002)
PNAS
   Abstract »    Full Text »    PDF »
The regulatory role for the ERCC3 helicase of general transcription factor TFIIH during promoter escape in transcriptional activation.
A. Fukuda, Y. Nogi, and K. Hisatake (2002)
PNAS
   Abstract »    Full Text »    PDF »
Crystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP.
N. Maita, K. Okada, K. Hatakeyama, and T. Hakoshima (2002)
PNAS
   Abstract »    Full Text »    PDF »
gamma -Glutamyl carboxylation: An extracellular posttranslational modification that antedates the divergence of molluscs, arthropods, and chordates.
P. K. Bandyopadhyay, J. E. Garrett, R. P. Shetty, T. Keate, C. S. Walker, and B. M. Olivera (2002)
PNAS
   Abstract »    Full Text »    PDF »
Targeted gene expression in transgenic Xenopus using the binary Gal4-UAS system.
K. O. Hartley, S. L. Nutt, and E. Amaya (2002)
PNAS
   Abstract »    Full Text »    PDF »
Molecular phylogenetic evidence for the independent evolutionary origin of an arthropod compound eye.
T. H. Oakley and C. W. Cunningham (2002)
PNAS
   Abstract »    Full Text »    PDF »
Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis.
R. B. Roberts, L. Min, M. K. Washington, S. J. Olsen, S. H. Settle, R. J. Coffey, and D. W. Threadgill (2002)
PNAS
   Abstract »    Full Text »    PDF »
Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity.
H. Kawasaki, H. Suemori, K. Mizuseki, K. Watanabe, F. Urano, H. Ichinose, M. Haruta, M. Takahashi, K. Yoshikawa, S.-I. Nishikawa, et al. (2002)
PNAS
   Abstract »    Full Text »    PDF »
Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS).
D. S. Howland, J. Liu, Y. She, B. Goad, N. J. Maragakis, B. Kim, J. Erickson, J. Kulik, L. DeVito, G. Psaltis, et al. (2002)
PNAS
   Abstract »    Full Text »    PDF »
Oscillatory brain states and learning: Impact of hippocampal theta-contingent training.
M. A. Seager, L. D. Johnson, E. S. Chabot, Y. Asaka, and S. D. Berry (2002)
PNAS
   Abstract »    Full Text »    PDF »
Two Recessive Gene Inheritance for Triallate Resistance in Avena fatua L..
A. J. Kern, T. M. Myers, M. Jasieniuk, B. G. Murray, B. D. Maxwell, and W. E. Dyer (2002)
J. Hered. 93, 48-50
   Abstract »    Full Text »    PDF »
Comparison of Human and Rat Metabolism of Molinate in Liver Microsomes and Slices.
W. T. Jewell and M. G. Miller (1999)
Drug Metab. Dispos. 27, 842-847
   Abstract »    Full Text »
Flavin adenine dinucleotide--dependent monooxygenase: its role in the sulfoxidation of pesticides in mammals.
N. Hajjar and E Hodgson (1980)
Science 209, 1134-1136
   Abstract »    PDF »
Novel activation mechanism for the promutagenic herbicide diallate.
I Schuphan, J. Rosen, and J. Casida (1979)
Science 205, 1013-1015
   Abstract »    PDF »
Dichloroacetamide antidotes for thiocarbamate herbicides: mode of action.
M Lay, J. Hubbell, and J. Casida (1975)
Science 189, 287-289
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)