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Science 26 April 1974:
Vol. 184. no. 4135, pp. 482 - 484
DOI: 10.1126/science.184.4135.482
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Articles

Somatostatin: Hypothalamic Inhibitor of the Endocrine Pancreas

Donna J. Koerker 1, Willy Ruch 1, Elliott Chideckel 1, Jerry Palmer 1, Charles J. Goodner 1, John Ensinck 1, and Charles C. Gale 1

1 Departments of Medicine, Physiology, and Biophysics, and Regional Primate Center, School of Medicine, University of Washington, Seattle

Somatostatin, a hypothalamic peptide that inhibits the secretion of pituitary growth hormone, inhibits basal insulin secretion in fasted cats and rats. In fasted baboons both basal and arginine-stimulated secretion of insulin and glucagon are inhibited. Somatostatin appears to act directly on the endocrine pancreas. The action is dose-related, rapid in onset, and readily reversed.


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