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Science 26 April 1974:
Vol. 184. no. 4135, pp. 477 - 480
DOI: 10.1126/science.184.4135.477
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Articles

Mycoplasma Contamination of Cultured Amniotic Fluid Cells: Potential Hazard to Prenatal Chromosomal Diagnosis

E. L. Schneider 1, E. J. Stanbridge 2, C. J. Epstein 3, M. Golbus 3, G. Abbo-Halbasch 3, and G. Rodgers 3

1 Gerontology Research Center (National Institute of Child Health and Development), Baltimore, Maryland 21224
2 Department of Medical Microbiology, Stanford University, Stanford, California 94305
3 Department of Pediatrics, University of California-San Francisco

Amniotic fluid cell cultures were screened for mycoplasma contamination. Mycoplasma RNA's were observed in more than half the cultures examined. Karyotypic analyses of these contaminated cell cultures revealed a significant increase in chromosomal aberrations. These studies emphasize the need for screening for mycoplasma in cultured amniotic cells.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)