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Science 26 April 1974:
Vol. 184. no. 4135, pp. 468 - 471
DOI: 10.1126/science.184.4135.468
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Articles

Heterocytolysis by Macrophages Activated by Bacillus Calmette-Guérin: Lysosome Exocytosis into Tumor Cells

John B. Hibbs Jr. 1

1 Veterans Administration Hospital and Department of Medicine, Division of Infectious Diseases, University of Utah Medical Center, Salt Lake City 84112

The cytotoxic activity of activated macrophages against tumorigenic target cells appears to be mediated by lysosomal enzymes of activated macrophage origin. Lysosomes of activated macrophages are secreted directly into the cytoplasm of susceptible target cells, which subsequently undergo heterolysis. This reaction can be inhibited by agents which prevent the exocytosis of macrophage lysosomes (hydrocortisone) or which interfere with the action of lysosomal enzymes (trypan blue).


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Macrophage tumor killing: influence of the local environment.
J. Hibbs Jr, R. Taintor, H. Chapman Jr, and J. Weinberg (1977)
Science 197, 279-282
   Abstract »    PDF »
Turnover of Acetylcholine Receptors in Skeletal Muscle.
P. N. Devreotes and D. M. Fambrough (1976)
Cold Spring Harb Symp Quant Biol 40, 237-251
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)