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Science 12 April 1974:
Vol. 184. no. 4133, pp. 167 - 169
DOI: 10.1126/science.184.4133.167
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Articles

Parathyroid Secretion: Discovery of a Major Calcium-Dependent Protein

Byron Kemper 1, Joel F. Habener 2, Alexander Rich 3, and John T. Potts Jr. 4

1 Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
2 Endocrine Unit and Department of Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston 02114
3 Department of Biology, Massachusetts Institute of Technology
4 Endocrine Unit and Department of Medicine, Massachusetts General Hospital, and Harvard Medical School

Bovine parathyroid tissue incubated in vitro secretes a protein that is distinct from both parathyroid hormone and proparathyroid hormone and comprises about 50 percent of the total secreted protein. This protein appears to be an aggregate consisting of two or more subunits of molecular weight 70,000 as determined by polyacrylamide gel electrophoresis in sodium dodecyl sulfate. Although the function of this protein is unknown, the secretion rates of both the protein and parathyroid hormone respond in parallel to changes in the concentration of calcium in the medium.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
In Vivo Regulation of Chromogranin A Messenger Ribonucleic Acid in the Parathyroid by 1,25-Dihydroxyvitamin D: Studies in Normal Rats and in Chronic Renal Insufficiency.
E. Soliman, L. Canaff, J. Fox, and G. N. Hendy (1997)
Endocrinology 138, 2596-2600
   Abstract »    Full Text »    PDF »
Recent Advances in the Structure and Function of the Parathyroid Gland in Animals and the Effects of Xenobiotics.
C. C. Capen and T. J. Rosol (1989)
Toxicol Pathol 17, 333-345
   Abstract »    PDF »


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