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Science 12 April 1974:
Vol. 184. no. 4133, pp. 165 - 166
DOI: 10.1126/science.184.4133.165
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Articles

Erythrocyte Deformation in Human Muscular Dystrophy

Dale W. Matheson 1 and John L. Howland 2

1 Department of Anatomy, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033
2 Committee on Biochemistry, Bowdoin College, Brunswick, Maine 04011

Erythrocytes from patients with congenital muscular dystrophy exhibit dramatic surface deformation when observed with a scanning electron microscope. A similar alteration, but one affecting a smaller proportion of cells, occurs in the case of female carriers of the sex-linked Duchenne dystrophic condition. These observed changes in the erythrocyte surface may reflect a systemic defect in membrane properties.


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Elevations of Hemopexin Levels in Neuromuscular Disease.
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Biochemical Abnormalities of Erythrocyte Membranes in Duchenne Dystrophy: Adenosine Triphosphatase and Adenyl Cyclase.
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Pathogenesis of Muscular Dystrophies.
L. P. Rowland (1976)
Arch Neurol 33, 315-321
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Scanning Electron Microscopy Studies in Muscular Dystrophy.
S. E. Miller, A. D. Roses, and S. H. Appel (1976)
Arch Neurol 33, 172-174
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Erythrocyte Surface Membrane Alterations: Findings in Human and Animal Muscular Dystrophies.
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Erythrocytes in human muscular dystrophy.
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Erythrocytes in human muscular dystrophy.
T. Miale, J. Frias, and D. Lawson (1975)
Science 187, 453-454
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