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Science 5 April 1974:
Vol. 184. no. 4132, pp. 70 - 72
DOI: 10.1126/science.184.4132.70
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Articles

Biogenic Amines and Control of Melanophore Stimulating Hormone Release

Annette Bower 1, Mac E. Hadley 2, and Victor J. Hruby 3

1 Department of Biological Sciences. Mount St. Mary's College, Los Angeles, California 90049
2 Department of Biological Sciences, University of Arizona, Tucson 85721
3 Department of Chemistry, University of Arizona

Release of melanophore stimulating hormone (MSH) from the vertebrate pars intermedia is under inhibitory control by the hypothalamus. Removal of the rat pituitary or the neurointermediate lobe of the frog (Rana pipiens) to in vitro incubation medium results in rapid uninhibited release of MSH. This secretion is inhibited by norepinephrine, epinephrine, phenylephrine, and dopamine, and the inhibition is antagonized by agr-adrenergic receptor blocking agents. Isoproterenol stimulation of MSH secretion from isolated glands is blocked by pro-pranolol, a beta-adrenergic receptor antagonist. These results implicate dopaminergic or classical agr-adrenergic receptors (or both) in inhibition of MSH release by catecholamines, and implicate beta-adrenergic receptors in stimulation of MSH release by the bioamines.


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