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Science 22 March 1974:
Vol. 183. no. 4130, pp. 1202 - 1203
DOI: 10.1126/science.183.4130.1202
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Articles

Visna Virus Infection of American Lambs

Opendra Narayan 1, Arthur M. Silverstein 2, Donald Price 3, and Richard T. Johnson 4

1 Departments of Animal Medicine and Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
2 Department of Ophthalmology, Johns Hopkins University School of Medicine
3 Departments of Pathology and Neurology, Johns Hopkins University School of Medicine
4 Departmnents of Neurology and Microbiology, Johns Hopkins University School of Medicine

Random-bred fetal and 4-week-old American lambs, inoculated intracerebrally with visna virus, developed a persistent infection in the brain and sometimes in the lung. The pathologic changes present in these lambs were similar to the early lesions of visna in Icelandic sheep, thus providing a possible model for the study of virus-induced demyelinating disease.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Antigenic shift of visna virus in persistently infected sheep.
O Narayan, D. Griffin, and J Chase (1977)
Science 197, 376-378
   Abstract »    PDF »
Slow persistent infection caused by visna virus: role of host restriction.
A. Haase, L Stowring, P Narayan, D Griffin, and D Price (1977)
Science 195, 175-177
   Abstract »    PDF »
Hydrocephalus Produced by the 6/94 Virus: A Parainfluenza Type 1 Isolate From Multiple Sclerosis Brain Tissue.
H. M. Friedman, D. H. Gilden, F. S. Lief, L. B. Rorke, D. Santoli, and H. Koprowski (1975)
Arch Neurol 32, 408-413
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