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Science 22 March 1974:
Vol. 183. no. 4130, pp. 1198 - 1200
DOI: 10.1126/science.183.4130.1198
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Articles

Stimulation of 24,25-Dihydroxyvitamin D3 Production by 1,25-Dihydroxyvitamin D3

Y. Tanaka 1 and H. F. DeLuca 1

1 Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin, Madison 53706

Vitamin D-deficient rats produce [3H]1,25-dihydroxyvitamin D3 from [3H]25-hydroxyvitamin D3 regardless of dietary content of calcium or phosphate. A daily dose of 130 picomoles of 1,25-dihydroxyvitamin D3 for a period of 5 days reduces production of [3H]1,25-dihydroxyvitamin D3 to essentially zero and stimulates production of [3H]24,25-dihydroxyvitamin D3. A daily dose of 325 picomoles of 25-hydroxyvitamin D3 has a similar but less dramatic effect. On the other hand, 650 picomoles daily of 24,25-dihydroxyvitamin D3 given to vitamin D-deficient rats had no effect. Thus it appears that 1,25-dihydroxyvitamin D3 is an important factor in the regulation of kidney metabolism of 25-hydroxyvitamin D3.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Expression and Activity of Vitamin D-Metabolizing Cytochrome P450s (CYP1{alpha} and CYP24) in Human Nonsmall Cell Lung Carcinomas.
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Dynamic changes in circulating 1,25-dihydroxyvitamin D during reproduction in rats.
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Vitamin D Metabolism and Function.
H. F. DeLuca (1978)
Arch Intern Med 138, 836-847
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Vitamin D Endocrinology.
H. F. DeLUCA (1976)
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