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Science 15 March 1974:
Vol. 183. no. 4129, pp. 1096 - 1098
DOI: 10.1126/science.183.4129.1096
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Articles

Ecto-Enzyme of Granulocytes: 5'-Nucleotidase

Joseph W. DePierre 1 and Manfred L. Karnovsky 1

1 Department of Biological Chemistry, Harvard Medical School, Boston, Massachusetts 02115

The 5'-nucleotidase of guinea pig polymorphonuclear leukocytes is localized exclusively on the plasma membrane of intact cells. The active site of this enzyme faces the external medium, not the cytoplasm.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)