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Science 15 March 1974:
Vol. 183. no. 4129, pp. 1087 - 1089
DOI: 10.1126/science.183.4129.1087
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Articles

Selective Pancreatic Enzyme Secretion due to a New Peptide Called Chymodenin

Joel W. Adelson 1 and S. S. Rothman 1

1 Department of Physiology, University of California, San Francisco 94143

Chymodenin, a peptide newly isolated from porcine duodenum, elicited a rapid threefold increase in secretion of chymotrypsinogen while increasing secrelion of total protein by only, about 40 percent; lipase secretion was unaffected. The pancreas appears able, under chymodenin stimulation, to rapidly alter the transport of an individual enzyme as opposed to producing en masse secretion of enzyme.


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