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Science 1 March 1974:
Vol. 183. no. 4127, pp. 867 - 869
DOI: 10.1126/science.183.4127.867
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Articles

Human DNA Polymerase III (R-DNA Polymerase): Distinction from DNA Polymerase I and Reverse Transcriptase

Brian J. Lewis 1, John W. Abrell 1, R. Graham Smith 1, and Robert C. Gallo 1

1 Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20014

DNA polymerase III is an enzyme activity in eukaryotic cells which under certain conditions shows strong preference for polyadenylic acid as template when primed by oligodeoxythymidylate. Its first complete separation from other DNA polymerases in human lymphoblasts is reported. This enzyme is biochemically and immunologically distinct from DNA polymerase I and from viral reverse transcriptase from a primtate type C virus.


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Nomenclature of eukaryotic DNA polymerases.
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Relationships between Components in Primate RNA Tumor Viruses and in the Cytoplasm of Human Leukemic Cells: Implications to Leukemogenesis.
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