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Science 15 February 1974:
Vol. 183. no. 4125, pp. 671 - 673
DOI: 10.1126/science.183.4125.671
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Articles

Diphenylhydantoin: Effects on Calcium Metabolism in the Chick

M. Villareale 1, L. V. Gould 2, R. H. Wasserman 3, A. Barr 3, R. T. Chiroff 4, and W. H. Bergstrom 5

1 Department of Biochemistry, Upstate Medical Center, Syracuse, New York 13210
2 Department of Radiology, Upstate Medicine Center
3 New York State Veterinary College, Cornell University, Ithaca
4 Department of Orthopaedic Surgery, Upstate Medical Center
5 Department of Pediatrics, Upstate Medical Center

Rickets, hypocalcemia, decreased duodenal calcium transport, and reduction of calcium binding protein have been produced in chicks treated with diphenylhydantoin. These effects are directly related to diphenylhydantoin dose and inversely related to the intake of vitamin D3 (cholecalciferol).


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Stimulation in vitro by 1,25-dihydroxy-vitamin D3 of intestinal cell calcium uptake and calcium-binding protein.
T Freund and F Bronner (1975)
Science 190, 1300-1302
   Abstract »    PDF »
Calciferol Deficiency Here and Now.
W. H. BERGSTROM (1975)
Arch Pediatr Adolesc Med 129, 1137-1138
   Abstract »    PDF »


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