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Science 15 February 1974:
Vol. 183. no. 4125, pp. 663 - 664
DOI: 10.1126/science.183.4125.663
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Articles

Failure to Confirm Cyclic AMP as Second Messenger for Norepinephrine in Rat Cerebellum

Norma Lake 1 and Larry M. Jordan 1

1 Department of Physiology, Medical College, University of Manitoba, Winnipeg

Microiontophoretic applications of adenosine 3',5'-monophosphate (cyclic AMP) to spontaneously active, electrophysiologically identified Purkinje cells of the rat cerebellum failed to mimic the strong depressant action of norepinephrine on the same cells. These findings, in combination with a reevaluation of other studies, cast doubt on the hypothesis that cyclic AMP mediates the depressant actions of norepinephrine in the cerebellum.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Analogs of cyclic adenosine monophosphate: correlation of inhibition of Purkinje Neurons with Protein Kinase Activation.
G. Siggins and S. Henriksen (1975)
Science 189, 559-561
   Abstract »    PDF »
Dopamine receptors in the brain.
L. Iversen (1975)
Science 188, 1084-1089
   PDF »
Interpreting the Failures to Confirm the Depression of Cerebellar Purkinje Cells by Cyclic AMP.
F. E. Bloom, G. R. Siggins, and B. J. Hopper (1974)
Science 185, 627-629
   PDF »


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