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Science 15 February 1974:
Vol. 183. no. 4125, pp. 659 - 661
DOI: 10.1126/science.183.4125.659
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Articles

Adenosine 3',5'-Monophosphate: Inhibition of Complement-Mediated Cell Lysis

Michael Kaliner 1 and K. Frank Austen 1

1 Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, and Department of Medicine, Robert B. Brigham Hospital, Boston 02120

An increase in adenosine 3',5'-monophosphate (cyclic AMP) in rat mast cells, achieved by stimulating the cells with prostaglandin E1, by preventing cyclic AMP breakdown with aminophylline, or by adding exogenous dibutyryl cyclic AMP, prevented complement-mediated cytolysis as assessed by both histamine release and vital dye exclusion. Dibutyryl cyclic AMP also suppressed water-induced osmotic lysis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Lithium: a modulator of cyclic AMP-dependent events in lymphocytes?.
E. Gelfand, H. Dosch, B Hastings, and A Shore (1979)
Science 203, 365-367
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)