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Science 8 February 1974:
Vol. 183. no. 4124, pp. 537 - 538
DOI: 10.1126/science.183.4124.537
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Articles

Serotonin Storage in Platelets: Estimation of Storage-Packet Size

Jonathan L. Costa 1, Thomas S. Reese 1, and Dennis L. Murphy 2

1 Laboratory of Neuropathology and Neuroanatomical Sciences, National Institiute of Neurological Diseases and Stroke, Bethesda, Maryland 20014
2 Laboratory of Clinical Science, National Institlte of Mental Health, Bethesda, Maryland 20014

Storage-body diameter and volume, and the number of molecules of serotonin contained in a storage body, were estimated for blood platelets. In the human, 5.23 x 105 molecules of serotonin are contained in a storage body 198 nanometers in diameter, while in the cat, 31.2 x 105 molecules of this amine are contained in a storage body 298 nanometers in diameter.


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