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Science 8 February 1974:
Vol. 183. no. 4124, pp. 525 - 526
DOI: 10.1126/science.183.4124.525
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Articles

Tracheobronchial Epithelial Multinucleation in Malignant Disease

J. Chalon 1, J. S. Katz 1, S. Ramanathan 1, M. Ambiavagar 1, and L. R. Orkin 1

1 Anesthesiology Department, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461

Multinucleated tracheobronchial ciliated epithelial cells seen in smears from 112 patients suffering from a wide variety of malignant tumors were found to be 2.08 times more numerous than in a control group comparable in sex, age (decades), and smoking habit but without prediagnosed malignancies. The recognition of this phenomenon may lead to the development of a new test for the diagnosis of occult cancer and may open new pathways for investigation of cancer-host relationships.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)