Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 1 February 1974:
Vol. 183. no. 4123, pp. 430 - 432
DOI: 10.1126/science.183.4123.430
Prev | Table of Contents | Next

Articles

Protein Kinase Translocation as an Early Event in the Hormonal Control of Uterine Contraction

Stanley G. Korenman 1, Ramesh C. Bhalla 2, Barbara M. Sanborn 3, and Reggie H. Stevens 4

1 Department of Internal Medicine, University of Iowa, and Veterans Administration Hospital, Iowa City 52240
2 Department of Anatomy, University of Iowa College of Medicine, Iowa City
3 Department of Reproductive Medicine, University of Texas School of Medicine, Houston
4 Department of Internal Medicine, University of Iowa, and Veterans Administration Hospital, Iowa City

beta-Adrenergic stimulation with isoproterenol inhibits contractility, increases cyclic adenosine monophosphate (AMP) concentration, decreases the concentration of unsaturated cyclic AMP receptor sites, and increases cyclic AMP-independent kinase in the uterus of ovariectomized rats. The total soluble kinase activity is reduced. The protein kinase activity lost from the cytosol was translocated to the microsomal fraction mostly in a cyclic AMP-independent form, suggesting a particulate substrate for the activated enzyme.

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)