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Science 1 February 1974:
Vol. 183. no. 4123, pp. 419 - 420
DOI: 10.1126/science.183.4123.419
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Articles

Inhibition of Cellular Mediated Immunity in Marihuana Smokers

Gabriel G. Nahas 1, Nicole Suciu-Foca 1, Jean-Pierre Armand 1, and Akira Morishima 1

1 Departments of Anesthesiology, Surgery, and Pediatrics, College of Physicians & Surgeons of Columbia University, New York 10032

The cellular mediated immunity of 51 young chronic marihuana smokers. as evaluated by the lyomphocyte response in vitro to allogeneic cells and to phytohemagglutinin, was significantly decreased and similar to that of patients in whom impairment of T (thymus derived) cell immunity is known to occur. This inhibition of blastogenesis might be related to an impairment of DNA synthesis.


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