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Science 18 January 1974:
Vol. 183. no. 4121, pp. 217 - 218
DOI: 10.1126/science.183.4121.217
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Articles

Aging Increases Susceptibility of Mouse Skin to DMBA Carcinogenesis Independent of General Immune Status

P. Ebbesen 1

1 Institute of Medical Microbiology, 22 Juliane Maries Vej, DK-2100 Copenhagen, Denmark

The dependence of chemical carcinogenesis on age of target tissue was studied by repeated DMBA-treatment of mouse skin grafted from old and young syngeneic donors to young recipients. Carcinomas developed on 39 percent (1.6/41) of grafts from old donors and on 12 percent (5/41) of grafts from young donors. The incidence of nonskin lymphoid tumors was highest in male recipients bearing grafts from old donors.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Some Gerontologic Considerations in the Practice of Dermatology.
B. A. Gilchrest (1979)
Arch Dermatol 115, 1343-1346
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Science. ISSN 0036-8075 (print), 1095-9203 (online)