Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 11 January 1974:
Vol. 183. no. 4120, pp. 86 - 87
DOI: 10.1126/science.183.4120.86
Prev | Table of Contents | Next

Articles

Guanylate Cyclase: Inhibition by Light in Retinal Photoreceptors

Richard E. Bensinger 1, R. Theodore Fletcher 1, and Gerald J. Chader 1

1 Laboratory of Vision Research National Eye Institute, Bethesda, Maryland 20014

Guanylate cyclase activity of retinal rod outer segments was measured by an assay procedure that minimizes the technical problems caused by the high activity of cyclic nucleotide phosphodiesterase in neural tissue. Cyclase activity in rods is significantly higher than in brain. Moreover, activity is two-fold higher in dark-adapted rods than in light-bleached rods, a sensitivity that is lost when the preparation is treated with detergent.

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)