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Science 28 December 1973:
Vol. 182. no. 4119, pp. 1364 - 1365
DOI: 10.1126/science.182.4119.1364
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Articles

Linoleic Acid Hydroperoxide: Impaired Bacterial Uptake by Alveolar Macrophages, a Mechanism of Oxidant Lung Injury

A. Khandwala 1 and J. Bernard L. Gee 1

1 Lung Research Center and Department of Internal Medicine, Yale University, New Haven, Connecticut 06510

Exogenous linoleic acid hydroperoxide causes in vitro impairment of both bacterial uptake and the phagocytic stimulation of 14CO2 production from [1-14C]glucose in rabbit alveolar macrophages by an undefined effect on the cell membrane. This effect may be one mechanism for the defective pulmonary bacterial clearance characteristic of oxidant lung injury.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)