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Science 30 November 1973:
Vol. 182. no. 4115, pp. 935 - 937
DOI: 10.1126/science.182.4115.935
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Articles

Mammary Carcinoma: Enzymatic Block in Disialoganglioside Biosynthesis

T. W. Keenan 1 and D. James Morré 1

1 Departments of Animal Sciences, Botany and Plant Pathology, and Biological Sciences, Purdue University, West Lafayette, Indiana 47907

The sialyl transferase of disialoganglioside formation is depressed in mammary tumors induced in the rat by 7,12-dimethylbenz[a]anthracene. Specific activities of other glycosyltransferases of the pathway ceramide to monosialo-ganglioside are unchanged or elevated so that the ganglioside GM1 accumulates and higher gangliosides are depressed. These findings with a solid tumor are critical to an involvement of gangliosides in the cell-surface changes of tumorigenesis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Metastatic potential is positively correlated with cell surface sialylation of cultured murine tumor cell lines.
G Yogeeswaran and P. Salk (1981)
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Concomitant elevations in serum sialytransferase activity and sialic acid content in rats with metastasizing mammary tumors.
R. Bernacki and U Kim (1977)
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Biosynthesis and function of gangliosides.
P. Fishman and R. Brady (1976)
Science 194, 906-915
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