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Science 30 November 1973:
Vol. 182. no. 4115, pp. 933 - 934
DOI: 10.1126/science.182.4115.933
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Articles

Oscillation of Cyclic Adenosine Monophosphate Concentration during the Myocardial Contraction Cycle

Gary Brooker 1

1 Department of Pharmacology, University of Virginia School of Medicine, Charlottesville 22901

The concentration of adenosine 3',5'-monophosphate (cyclic AMP) rises and falls during each myocardial contraction cycle. Peak concentrations of cyclic AMP precede peak development of systolic tension. Epinephrine alters the normal oscillation in myocardial cyclic AMP and increases both diastolic and systolic concentrations of the cyclic nucleotide. These transient changes in myocardial cyclic AMP indicate a potential role for cyclic AMP as a beat-to-beat regulator of myocardial contractility.


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