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Science 30 November 1973:
Vol. 182. no. 4115, pp. 931 - 933
DOI: 10.1126/science.182.4115.931
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Articles

Ontogeny and Peripheralization of Thyimic Lymphocytes

James B. Turpen 1, E. Peter Volpe 1, and Nicholas Cohen 2

1 Department of Biology, Tulane University, New Orleans, Louisiana 70118
2 Department of Microbiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642

Reciprocal transplantation of undifferentiated thymic primordia between diploid and triploid chromosomally marked frog embryos has revealed that thymic lymphocytes are ontogenically derived from elements of the thymic primordium rather than from blood-borne stem cells that migrated into the developing organ. Virtually all the lymphocytes in the spleen, kidneys, and bone marrow of adult frogs are descendants of these original thymic stem lymphocytes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Xenopus homologue of aml-1 reveals unexpected patterning mechanisms leading to the formation of embryonic blood.
W. Tracey, M. Pepling, M. Horb, G. Thomsen, and J. Gergen (1998)
Development 125, 1371-1380
   Abstract »    PDF »
Thymus: central role in the immune system of the frog.
E. Volpe and J. Turpen (1975)
Science 190, 1101-1103
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)