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Science 30 November 1973:
Vol. 182. no. 4115, pp. 925 - 927
DOI: 10.1126/science.182.4115.925
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Articles

Vasopressin and Neurophysin: High Concentrations in Monkey Hypophyseal Portal Blood

Earl A. Zimmerman 1, Peter W. Carmel 2, M. Kazim Husain 3, Michal Ferin 4, Myron Tannenbaum 5, Andrew G. Frantz 3, and Alan G. Robinson 6

1 Department of Neurology, College of Physicians and Surgeons, Columbia University, New York 10032
2 Department of Neurosurgery, College of Physicians and Surgeons
3 Department of Medicine, College of Physicians and Surgeons
4 International Institute for the Study of Human Reproduction and Department of Obstetrics and Gynecology, College of Physicians and Surgeons
5 Departments of Urology and Pathology, College of Physicians and Surgeons
6 Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213

Vasopressin and its binding protein, neurophysin, were measured by radioimmunoassay in the hypophyseal portal blood of monkeys after cannulation of individual long portal veins. Mean vasopressin concentrations (13,800 picograms per milliliter) in portal blood were more than 300 times as high as those in the systemic circulation (42 picograms per milliliter). Neurophysin concentration was approximately 25 times as high in portal as in systemic blood. By immunoperoxidase techniques, high concentrations of neurophysin were demonstrated around portal capillaries of the median eminence. These studies indicate direct secretion of vasopressin and neurophysin into the portal circulation; the quantities secreted during stress may be sufficient to exert significant effects on secretion of anterior pituitary hormone.


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