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Science 16 November 1973:
Vol. 182. no. 4113, pp. 725 - 727
DOI: 10.1126/science.182.4113.725
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Articles

Lead Metabolism in the Normal Human: Stable Isotope Studies

Michael B. Rabinowitz 1, George W. Wetherill 1, and Joel D. Kopple 2

1 Institute of Geophysics and Department of Planetary and Space Science, University of California, Los Angeles 90024
2 Medical and Research Services, Veterans Administration, Wadsworth Hospital Center, and Department of Medicine, School of Medicine, University of California, Los Angeles

Kinetic and metabolic balance studies in a healthy man fed a diet normal in lead content and labeled with lead-204 indicated that approximately two-thirds of his assimilated lead was dietary in origin; the remainder was inhaled. Kinetic analysis shows that the isotopic data can be interpreted by a three-compartment model.


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