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Science 16 November 1973:
Vol. 182. no. 4113, pp. 724 - 725
DOI: 10.1126/science.182.4113.724
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Articles

Effects of Dibutyryl Cyclic AMP on Restoration of Function of Damaged Sciatic Nerve in Rats

Michael Pichichero 1, Bernard Beer 2, and Donald E. Clody 2

1 Department of Pharmacology, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642
2 Squibb Institute for Medical Research, Princeton, New Jersey 08540

In two experiments, the sciatic nerve of rats was either crushed or hemisected, and N6,O2-dibutyryl adenosine 3',5'-monophosphate or saline was injected intramuscularly near the site of the lesion. In both types of nerve damage, the sensorimotor functions of animals treated with N6,O2-dibutyryl adenosine 3',5'-monophosphate returned earlier than did those of saline-treated control animals.


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T. M. Brushart, P. N. Hoffman, R. M. Royall, B. B. Murinson, C. Witzel, and T. Gordon (2002)
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Science. ISSN 0036-8075 (print), 1095-9203 (online)