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Science 16 November 1973:
Vol. 182. no. 4113, pp. 712 - 713
DOI: 10.1126/science.182.4113.712
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Articles

Experimental Alcoholic Hepalitis: A New Primate Model

Emanuel Rubin 1 and Charles S. Lieber 2

1 Department of Pathology, Mount Sinai School of Medicine, New York 10029
2 Department of Medicine, Mount Sinai School of Medicine, and Section of Liver Disease and Nutrition, Veterans Administration Hospital, Bronx, New York 10463

Research into the pathogenesis of alcoholic cirrhosis has suffered from the lack of an animal model of alcoholic hepatitis, considered by many to be the link between alcoholic fatty liver and cirrhosis. The entire constellation of histologic features characteristic of alcoholic hepatitis has been produced for the first time in baboons by administration of ethanol with a nutritionally adequate diet. This includes fat, necrosis. inflammation, alcoholic hyaline, fibrosis, and central hyaline sclerosis.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)