Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 2 November 1973:
Vol. 182. no. 4111, pp. 499 - 501
DOI: 10.1126/science.182.4111.499
Prev | Table of Contents | Next

Articles

Dopaminergic Terminals in the Rat Cortex

A. M. Thierry 1, G. Blanc 1, A. Sobel 1, L. Stinus 2, and J. Glowinski 3

1 Groupe de Neuropharmacologie Biochimique, Collège de France, Paris 5
2 Laboratoire de Psychophysiologie, Faculté des Sciences, Université de Bordealux. Talence 33, France
3 Groupe de Neuropharinacologie Biochimique, Collège de France

The destruction of ascending noradreniergic pathways by bilateral microinjections of 6-hydroxydopamnine made laterally to the pedunculus cerebellaris superior completely abolished the in vitro synthesis of [3H]norepinephrine from L-[3H]tyrosine in slices and in synaptosomes of the rat cortex. However, normal [3H]dopamine synthesis could still be observed in both cortical preparations from animals with lesions. These results provide the first biochemical support for the existence of dopaminergic terminals independent of noradrenergic terminals in the rat cortex.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Dopamine Modulates Temporal Dynamics of Feedforward Inhibition in Rat Prefrontal Cortex In Vivo.
P. L. Tierney, A. M. Thierry, J. Glowinski, J. M. Deniau, and Y. Gioanni (2008)
Cereb Cortex 18, 2251-2262
   Abstract »    Full Text »    PDF »
Functional Coupling between the Prefrontal Cortex and Dopamine Neurons in the Ventral Tegmental Area.
M. Gao, C.-L. Liu, S. Yang, G.-Z. Jin, B. S. Bunney, and W.-X. Shi (2007)
J. Neurosci. 27, 5414-5421
   Abstract »    Full Text »    PDF »
Subthalamic nucleus stimulation modulates afferent inhibition in Parkinson disease.
A. Sailer, D. I. Cunic, G. O. Paradiso, C. A. Gunraj, A. Wagle-Shukla, E. Moro, A. M. Lozano, A. E. Lang, and R. Chen (2007)
Neurology 68, 356-363
   Abstract »    Full Text »    PDF »
Genetic evidence for the bidirectional modulation of synaptic plasticity in the prefrontal cortex by D1 receptors.
Y.-Y. Huang, E. Simpson, C. Kellendonk, and E. R. Kandel (2004)
PNAS 101, 3236-3241
   Abstract »    Full Text »    PDF »
Disruption of information processing in the supplementary motor area of the MPTP-treated monkey: A clue to the pathophysiology of akinesia?.
L. Escola, Th. Michelet, F. Macia, D. Guehl, B. Bioulac, and P. Burbaud (2003)
Brain 126, 95-114
   Abstract »    Full Text »    PDF »
Delayed Mesolimbic System Alteration in a Developmental Animal Model of Schizophrenia.
Y. Goto and P. O'Donnell (2002)
J. Neurosci. 22, 9070-9077
   Abstract »    Full Text »    PDF »
Network Synchrony in the Nucleus Accumbens In Vivo.
Y. Goto and P. O'Donnell (2001)
J. Neurosci. 21, 4498-4504
   Abstract »    Full Text »    PDF »
Ventral Tegmental Area Afferents to the Prefrontal Cortex Maintain Membrane Potential 'Up' States in Pyramidal Neurons via D1 Dopamine Receptors.
B. L. Lewis and P. O'Donnell (2000)
Cereb Cortex 10, 1168-1175
   Abstract »    Full Text »    PDF »
Dopamine Modulation of Membrane and Synaptic Properties of Interneurons in Rat Cerebral Cortex.
F.-M. Zhou and J. J. Hablitz (1999)
J Neurophysiol 81, 967-976
   Abstract »    Full Text »    PDF »
Differential Influence of Associative and Nonassociative Learning Mechanisms on the Responsiveness of Prefrontal and Accumbal Dopamine Transmission to Food Stimuli in Rats Fed Ad Libitum.
V. Bassareo and G. Di Chiara (1997)
J. Neurosci. 17, 851-861
   Abstract »    Full Text »    PDF »
The anatomical relationships of the prefrontal cortex with limbic structures and the basal ganglia.
H. J. Groenewegen, C. I. Wright, and H. B. M. Uylings (1997)
J Psychopharmacol 11, 99-106
   Abstract »    PDF »
Dopamine Metabolism in the Cerebrospinal Fluid of Drug-Free Schizophrenic Patients With and Without Cortical Atrophy.
D. P. van Kammen, W. B. van Kammen, L. S. Mann, T. Seppala, and M. Linnoila (1986)
Arch Gen Psychiatry 43, 978-983
   Abstract »    PDF »
Widespread distribution of brain dopamine receptors evidenced with [125I]iodosulpride, a highly selective ligand.
M. Martres, M. Bouthenet, N Sales, P Sokoloff, and J. Schwartz (1985)
Science 228, 752-755
   Abstract »    PDF »
Clomipramine-Induced Mania in Unipolar Depression.
J. D. van Scheyen and D. P. van Kammen (1979)
Arch Gen Psychiatry 36, 560-565
   Abstract »    PDF »
Norepinephrine in chronic paranoid schizophrenia: above-normal levels in limbic forebrain.
I. Farley, K. Price, E McCullough, J. Deck, W Hordynski, and O Hornykiewicz (1978)
Science 200, 456-458
   Abstract »    PDF »
Brain self-stimulation: direct evidence for the involvement of dopamine in the prefrontal cortex.
F Mora and R. Myers (1977)
Science 197, 1387-1389
   Abstract »    PDF »
Depletion of brain catecholamines: failure of ocular dominance shift after monocular occlusion in kittens.
T Kasamatsu and J. Pettigrew (1976)
Science 194, 206-209
   Abstract »    PDF »
Dopamine receptors in the brain.
L. Iversen (1975)
Science 188, 1084-1089
   PDF »
Serum Prolactin Levels in Unmedicated Schizophrenic Patients.
H. Y. Meltzer, E. J. Sachar, and A. G. Frantz (1974)
Arch Gen Psychiatry 31, 564-569
   Abstract »    PDF »
Dopamine Nerve Terminals in the Rat Limbic Cortex: Aspects of the Dopamine Hypothesis of Schizophrenia.
T. Hokfelt, A. Ljungdahl, K. Fuxe, and O. Johansson (1974)
Science 184, 177-179
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)