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Science 2 November 1973:
Vol. 182. no. 4111, pp. 497 - 499
DOI: 10.1126/science.182.4111.497
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Articles

Fatty Acyl-Coenzyme A Elongation in Brain of Normal and Quaking Mice

Israel Goldberg 1, Ishaiahu Shechter 1, and Konrad Bloch 1

1 James Bryant Conant Laboratories, Harvard University, Cambridge, Massachusetts 02138

Microsomal enzyme systems from mouse brain that catalyze, respectively, the elongation of palmitoyl-coenzyme A (palmitoyl-CoA), stearoyl-CoA, or arachidyl-CoA appear and reach maximal activity at different times after birth of the animal. A specific C20-CoA elongating system exists in mouse brain in addition to the previously recognized C16-CoA and Cl8-CoA elongating enzymes. The C20-CoA elongation system is severely reduced in the mutant quaking mouse.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)